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Being a twin, triplet or more is a truly unique experience. Many adult multiples talk about the special bond that they share with their twin or triplet. The unique relationship can also bring challenges — relationships between multiples can be difficult to navigate and may not always run smooth.

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The feat is a first for nonhuman primates, and despite limitations, it could lead to batches of genetically uniform monkeys for biomedical research. Previous attempts to clone monkeys through the Dolly method, known as somatic cell nuclear transfer SCNTproduced viable embryos but they failed to mature into healthy animals. The technique starts with taking the nucleus of a cell from a tissue like skin, and inserting it into an animal egg that has had its own DNA-carrying nucleus removed.

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Variation in DNA methylation is being increasingly associated with health and disease outcomes. Although DNA methylation is hypothesized to be a mechanism by which both genetic and non-genetic factors can influence the regulation of gene expression, little is known about the extent to which DNA methylation at specific sites is influenced by heritable as well as environmental factors. We quantified DNA methylation in whole blood at age 18 in a birth cohort of 1, individuals comprising monozygotic MZ and same-sex dizygotic DZ twin pairs.

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Metrics details. Low birth weight is associated with an increased adult metabolic disease risk. It is widely discussed that poor intra-uterine conditions could induce long-lasting epigenetic modifications, leading to systemic changes in regulation of metabolic genes.

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About 32 out of every people is a twin. Identical twinning seems to be due just to chance. The percent of people who are twins differs by race and ethnicity.

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Twins needed! The following list of studies is actively recruiting twins to participate in their research. If you are interested, please contact the MATR for more information!

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Identical twins are identical, right? After all, they derive from just one fertilized egg, which contains one set of genetic instructions, or genomeformed from combining the chromosomes of mother and father. But experience shows that identical twins are rarely completely the same.

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Birth weight can be seen as a proxy for environmental conditions during prenatal development. Identical twin pairs discordant for birth weight provide an extraordinary model for investigating the association between birth weight and adult life health while controlling for not only genetics but also postnatal rearing environment. We performed an epigenome-wide profiling on blood samples from pairs of adult monozygotic twins discordant for birth weight to look for molecular evidence of epigenetic signatures in association with birth weight discordance.

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Metrics details. A low birth weight has been extensively related to poor adult health outcomes. Birth weight can be seen as a proxy for environmental conditions during prenatal development.


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